Dysautonomia Decoded

Dysautonomia Decoded

"Just Exercise More." Here's What Happens at a Cellular Level When You Do.

A 2024 Nature Communications study examined muscle tissue before and after exercise in Long COVID patients with PEM. Here is what they found and what the debate around it looks like.

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Dysautonomia Decoded
Jul 19, 2026
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Today let’s decode one of the most debated papers in the Long COVID literature. Published in Nature Communications in January 2024 by Appelman, Charlton and colleagues at Amsterdam UMC, it did something deceptively simple: it took muscle biopsies from Long COVID patients with post-exertional malaise, made them exercise to the point of triggering a crash…

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