Post-Exertional Malaise (PEM): What Is Actually Happening in Your Body When You Crash

PEM is one of the most debilitating and least understood features of Long COVID, ME/CFS and dysautonomia. New research is finally starting to map the mechanisms. Here is what we know.

Today let’s decode post-exertional malaise (PEM). Unfortunately for a lot of CSF/ME or Long-COVID/ PoTS patients may know what this it feels like… but what is actually happening inside the body when even mild exertion triggers an extreme crash that can last hours, days or longer.

For a long time the honest answer was that we don’t really know. Thankfully…